Investigator Initiated Studies

NHSc Clinical Research Priorities

Investigate the impact of Nutrition on the following conditions

  • Pediatric allergy

    Pediatric allergy:

    • Management of cow’s milk protein allergy

  • Critical Care

    Critical Care:

    • Nutritional management in the ICU

    • Gastrointestinal dysfunction

    • Metabolic modulation in critical illness

    • Post‑ICU nutritional continuity and recovery

  • Neurological Impairment

    Neurological Impairment:

    • Cerebral Palsy

  • Weight management

    Weight Management:

    • GLP-1 therapy-related e.g, muscle and bone health, gastro-intestinal health, malnutrition in overweight/obesity

    • Weight loss maintenance after GLP1 based therapy

  • Oncology

    Oncology:

    • Pediatric cancer

    • Upper GI cancer

    • Head & Neck cancer

  • Healthy Aging & Women´s Health

    Healthy Aging & Women´s Health:

    • Gut health, musculoskeletal health, brain functions, cognition

    • Peri/menopause

  • Gastrointestinal

    Gastrointestinal:

    • Chronic Pancreatitis & EPI

    • Short Bowel Syndrome

    • Malabsorption

    • Cystic Fibrosis

  • Geriatric Care

    Geriatric Care:

    • Age-related malnutrition

    • Frailty & Sarcopenia

Key definition

Investigator Initiated Study: An Investigator Initiated Study (IIS) or Trial (IIT) is a study involving human research developed and sponsored by an independent external entity.

The study could be interventional (incl. RCT) or non-interventional in the form of a Real World Evidence trial. The investigator or affiliated study sponsor has responsibility for study conception, design, operational execution, data handling, data analysis/interpretation, subsequent reporting/ publication, and ensuring compliance with all local laws and regulations.

The IIS sponsor may request support from NHSc in the form of full grant or partial funding, NHSc product supply or both.

Interventional & non-interventional (RWE)

Monthly meetings

Health Economics & Outcomes Research click here

Key application files requirement list

  • IIS Application Form

    (will appear when
    submitting application)

  • Synopsis, including budget and timelines estimate

  • Investigator’s CV

    (or biography)

  • GCP Certificate

    (or equivalent, reference to experience in conducting clinical trials).

IIS are evaluated by a Nestlé Health Science (NHSc) Review Committee that is an internal
scientific and medical review panel for all Investigator Initiated Proposals requiring
funding and/or NHSc products

The IIS Review Committee evaluates the following aspects:

  • The IIS is medically and scientifically sound and aimed at enhancing the Nutrition, Health and Wellness of individuals in strategic areas of interest to NHSc

  • The Sponsor-investigator commits to comply with all applicable local laws and with GCP

  • The rights of subjects are respected

  • The Sponsor-investigator agrees to transparently disclose NHSc support of the study to the study participants, to the ethics committee and in any scientific publication of the study results

  • The Sponsor-investigator commits to disseminate the study results to the research community in an appropriate, transparent and timely manner

  • There is transparency about other sources of the funding apart from NHSc and no concerns

  • Based on risk assessment, there are no legal/ compliance/ market risks identified